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These results show that triggering the ceramide signaling pathway activates MMP-1 gene expression via three distinct MAPK pathways, i.e. In addition, ceramide-dependent induction of MMP-1 expression is potently prevented by PD 98059, a selective inhibitor of MEK1 activation, and by specific p38 inhibitor SB 203580.

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Activation of MMP-1 promoter by C 2-ceramide is also effectively inhibited by kinase-deficient forms of ERK1/2 kinase (MEK1/2) activator Raf-1, ERK1 and ERK2, SAPK/JNK activator SEK1, or SAPKβ.

Stimulation of MMP-1 promoter activity by C 2-ceramide is dependent on the presence of a functional AP-1 cis-element and is entirely inhibited by overexpression of MAPK inhibitor, dual specificity phosphatase CL100 (MAPK phosphatase-1). C 2-ceramide activates three distinct mitogen-activated protein kinases (MAPKs) in dermal fibroblasts, i.e.extracellular signal-regulated kinase 1/2 (ERK1/2), stress-activated protein kinase/Jun N-terminal-kinase (SAPK/JNK), and p38. Here, we show that triggering the ceramide pathway by sphingomyelinase or C 2- and C 6-ceramide enhances collagenase-1 (matrix metalloproteinase-1 MMP-1) gene expression by fibroblasts. A Review is only visible if it has a grade from 1 to 10 and if it has review text more than 30 characters.Inflammatory cytokines tumor necrosis factor-α and interleukin-1 trigger the ceramide signaling pathway, initiated by neutral sphingomyelinase-elicited hydrolysis of cell membrane phospholipid sphingomyelin to ceramide, a new lipid second messenger. This field includes Videospace user reviews of the movie.

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Note! You can not add releases to movie collection so if you are planning to create a collection of your blu ray collection for example, rather create a Release collection and add your blurays there :)

Collection can be for example Watched films, My favourite films, Movies that I hate etc. 2005 Harri Savander 2006 Panu Kurkinen 2007 Lauri Kivinen 2008 Jyri Suhonen 2009 Lauri Kivinen 2010 Jari Komulainen 2011 Roni Vartama 2012 Roni Vartama 2013 Saku Hakkarainen 2014 Valentin Ikonen. You can share your collections for example on facebook. 2015 Iina Lehtinen 2016 Jutta Myllyniemi 2017 Roosa Hussa 2018 Sohvi Korhonen 2019 Selina Saarenpää 2020 Salla Tegelberg 2021 Tiia Jokela. You can create Movie collection in your page and then you can start adding movies to your new collection by pressing add to your collection button. You can add a movie to your Videospace collection. taavitsainen-niina-kurkinen-tiina/563293716 T22:28:16+03:00 1.0. Electric Guitar Ilja Saastamoinen, Matti Kurkinen. If the same distributor company has released a movie in the same country in the same format but the cover package is different, these are count as seperate Releases. Created by Petja Peltomaa - Starring Lena Merilinen, Tiina Lymi, Leena Pysti, Iina Kuustonen. Release is made unique by release country, format, distributor company and also the package of release.

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Digital dowloads does not qualify releases on streaming services such as Netflix or HBO, unless user can legally download releases on his/hers computer. Digital dowloads are files that user can dowload on his/hers computer. VHS and BETA tapes, optical DVD, Bluray, UHD and Laserdisc discs. Distribution, which is done with a physical or digital dowload. in certain country or continent released by distributor company.

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In Videospace database Release is a distribution of Movie, TV series or documentary etc. Iita Kurkinen: Birthdate: July 18, 1887: Birthplace: Iisalmi, Finland: Death: Immediate Family: Daughter of Juho Kurkinen and Tiina Maria Heiskanen Sister of Otto Teodor Kurkinen Anna Maria Kurkinen Juho Heikki Kurkinen and Riitta Tiina Kurkinen. For example Die Hard Quadrilogy Bluray box includes four Die Hard Movies.

A Release usually includes one Movie but the database also supports Releases that can include multiple Movies. For example Movie Die Hard has finnish releases in VHS and Bluray formats. A Movie can have releases from multiple different countries, formats, covers and released by different releasing companies. Videospace database is shared between two main categories: MOVIES and their RELEASES. In order to have your collection to be visible on page, it needs to have a rating and text must be more than 30 characters. If you dont have a suitable collection, you can add one by clicking 'add new collection' button. ) cover page cover page b-side poster photo still promo material backcoverįirst select a collection you wish to add your review. Currently effective rating: Other rating: